Cell rupture and cell disruption, & homogenizing system

System Options

• IQ, OQ and PQ support.
• SIP including necessary instrumentation and steam traps.
• Systems meeting hazardous area classifications including Class 1 Div 1.
• Dual redundant PLC or DCS based controls.
• CE compliance (for Europe).
• WFI break tank for aseptic plunger flush.
• WFI aseptic plunger flush cooler.
• Product pre-cooler
• Second homogenizing stage.

Cell rupture and cell disruption

Cell disruption - bacteria, yeast, algae and plant cells. The Niro Soavi VHP System offers an efficient method of cell rupture with yields of over 90% being achieved with a single pass without the addition of expensive chemicals or agents, therefore maintaining product quality and reducing production time.

Saccharomyces Cerevisiae Cell Disruption
Before cell disruption		After 1000 bar x 2 pass giving a cell breakage of 95%

GEA Liquid Processing cell rupture skid for biologic cell lysing. The homogenizer feature the high efficiency sharp profile rupture valve type R which enable cell disruption at lower pressures.

GEA Niro Soavi VHP cell rupture (cell disruption) systems can be easily scaled from the lab and pilot systems through to the commercial size systems. Also, the homogenizer meets all the ASME BPE requirements for cell disruptors and the compression head has non shedding components and parts due to material selection and design.

Homogenizing system for particle size reduction

Particle size reduction - oral dosage, intravenous parenterals, nano-suspensions, nanoemulsions and liposome's. The GEA Niro Soavi VHP System reduces particle size efficiently and often at reduced pressure and fewer passes than competing technologies. This is due to the Niro Soavi sharp profile homogenizer valve type R.

GEA Niro Soavi R type sharp profile valve

IV Emulsion Particle Size Results
Pre-mixed not homogenized, particle size=5 µm		500 bar x 4 pass, particles dimension < 1 µm